abstract：:Poorly controlled type 2 diabetes mellitus is associated with the development of cardiovascular and renal complications, resulting in significant morbidity and mortality. Intensive glycemic control has been a major focus for clinical trials and novel drug development. However, narrow treatment strategies developed str...

journal_title：Journal of the American College of Cardiology

authors： Cherney DZ,Odutayo A,Aronson R,Ezekowitz J,Parker JD

更新日期：2019-11-19 00:00:00

abstract：BACKGROUND:Guidewire manipulation time is rarely used in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) strategies. OBJECTIVES:This study sought to develop an algorithm based on angiographic characteristics and guidewire manipulation time. METHODS:This study assessed 5,843 patients undergoing ...

journal_title：Journal of the American College of Cardiology

authors： Tanaka H,Tsuchikane E,Muramatsu T,Kishi K,Muto M,Oikawa Y,Kawasaki T,Hamazaki Y,Fujita T,Katoh O

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Major disparities between women and men in the diagnosis, management, and outcomes of acute coronary syndrome are well recognized. OBJECTIVES:The aim of this study was to evaluate the impact of implementing a high-sensitivity cardiac troponin I assay with sex-specific diagnostic thresholds for myocardial in...

journal_title：Journal of the American College of Cardiology

authors： Lee KK,Ferry AV,Anand A,Strachan FE,Chapman AR,Kimenai DM,Meex SJR,Berry C,Findlay I,Reid A,Cruickshank A,Gray A,Collinson PO,Apple FS,McAllister DA,Maguire D,Fox KAA,Newby DE,Tuck C,Keerie C,Weir CJ,Shah ASV,

更新日期：2019-10-22 00:00:00

abstract：BACKGROUND:Ibrutinib has revolutionized treatment for several B-cell malignancies. However, a recent clinical trial where ibrutinib was used in a front-line setting showed increased mortality during treatment compared with conventional chemotherapy. Cardiovascular toxicities were suspected as the culprit but not direct...

journal_title：Journal of the American College of Cardiology

authors： Salem JE,Manouchehri A,Bretagne M,Lebrun-Vignes B,Groarke JD,Johnson DB,Yang T,Reddy NM,Funck-Brentano C,Brown JR,Roden DM,Moslehi JJ

更新日期：2019-10-01 00:00:00

abstract：:Concepts of atherogenesis have evolved considerably with time. Early animal experiments showed that a cholesterol-rich diet could induce fatty lesion formation in arteries. The elucidation of lipoprotein metabolism ultimately led to demonstrating the clinical benefits of lipid lowering. The view of atheromata as bland...

journal_title：Journal of the American College of Cardiology

authors： Libby P,Hansson GK

更新日期：2019-09-24 00:00:00

abstract：BACKGROUND:Arterial 18fluorodeoxyglucose (FDG) positron emission tomography (PET) is considered a measure of atherosclerotic plaque macrophages and is used for quantification of disease activity in clinical trials, but the distribution profile of FDG across macrophages and other arterial cells has not been fully clarif...

journal_title：Journal of the American College of Cardiology

authors： Al-Mashhadi RH,Tolbod LP,Bloch LØ,Bjørklund MM,Nasr ZP,Al-Mashhadi Z,Winterdahl M,Frøkiær J,Falk E,Bentzon JF

更新日期：2019-09-03 00:00:00

abstract：:Diabetes mellitus is one of the most common chronic medical conditions, and is a risk factor for the development of atrial fibrillation (AF). The presence of diabetes in patients with AF is associated with increased symptom burden and increased cardiovascular and cerebrovascular mortality. The pathophysiology of diabe...

journal_title：Journal of the American College of Cardiology

authors： Wang A,Green JB,Halperin JL,Piccini JP Sr

更新日期：2019-08-27 00:00:00

abstract：BACKGROUND:Patients with high stroke risk and atrial fibrillation who are unsuitable to oral anticoagulants (OACs) require other stroke prevention strategies. A novel permanent coil filter directly placed into both common carotid arteries (CCAs) was designed to capture emboli >1.4 mm in diameter. OBJECTIVES:The multic...

journal_title：Journal of the American College of Cardiology

authors： Reddy VY,Neuzil P,de Potter T,van der Heyden J,Tromp SC,Rensing B,Jiresova E,Dujka L,Lekesova V

更新日期：2019-08-20 00:00:00

abstract：:Stroke survivors carry a high risk of recurrence. Antithrombotic medications are paramount for secondary prevention and thus crucial to reduce the overall stroke burden. Appropriate antithrombotic agent selection should be based on the best understanding of the physiopathological mechanism that led to the initial isch...

journal_title：Journal of the American College of Cardiology

authors： Del Brutto VJ,Chaturvedi S,Diener HC,Romano JG,Sacco RL

更新日期：2019-08-13 00:00:00

abstract：:For secondary prevention of coronary artery disease (CAD), oral antiplatelet therapy is essential. In case of coronary intervention, temporary dual antiplatelet therapy is mandatory as well. Recently, low-dose oral anticoagulation has entered the CAD arena. Atrial fibrillation (AF) is often seen in CAD and vice versa....

journal_title：Journal of the American College of Cardiology

authors： Verheugt FWA,Ten Berg JM,Storey RF,Cuisset T,Granger CB

更新日期：2019-08-06 00:00:00

abstract：:As new treatments continue to improve clinical outcomes in coronary artery disease (CAD) and heart failure, it is necessary to characterize the appropriate use of β-adrenergic receptor blockers (β-blockers) in the contemporary management of these conditions. This review examines the current evidence supporting β-block...

journal_title：Journal of the American College of Cardiology

authors： Joseph P,Swedberg K,Leong DP,Yusuf S

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Although heart failure with preserved ejection fraction (HFpEF) is considered a disease of the elderly, younger patients are not spared from this syndrome. OBJECTIVES:This study therefore investigated the associations among age, clinical characteristics, and outcomes in patients with HFpEF. METHODS:Using d...

journal_title：Journal of the American College of Cardiology

authors： Tromp J,Shen L,Jhund PS,Anand IS,Carson PE,Desai AS,Granger CB,Komajda M,McKelvie RS,Pfeffer MA,Solomon SD,Køber L,Swedberg K,Zile MR,Pitt B,Lam CSP,McMurray JJV

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:The optimal timing of intervention in patients with asymptomatic severe aortic stenosis (AS) remains controversial. OBJECTIVES:This multicenter study sought to test and validate the prognostic value of the staging of cardiac damage in patients with asymptomatic moderate to severe AS. METHODS:This study ret...

journal_title：Journal of the American College of Cardiology

authors： Tastet L,Tribouilloy C,Maréchaux S,Vollema EM,Delgado V,Salaun E,Shen M,Capoulade R,Clavel MA,Arsenault M,Bédard É,Bernier M,Beaudoin J,Narula J,Lancellotti P,Bax JJ,Généreux P,Pibarot P

更新日期：2019-07-30 00:00:00

abstract：BACKGROUND:The CTOT-11 (Prevention of Cardiac Allograft Vasculopathy Using Rituximab Therapy in Cardiac Transplantation [Clinical Trials in Organ Transplantation-11]) study was a randomized, placebo-controlled, multicenter, double-blinded clinical trial in nonsensitized primary heart transplant (HTX) recipients. OBJEC...

journal_title：Journal of the American College of Cardiology

authors： Starling RC,Armstrong B,Bridges ND,Eisen H,Givertz MM,Kfoury AG,Kobashigawa J,Ikle D,Morrison Y,Pinney S,Stehlik J,Tripathi S,Sayegh MH,Chandraker A,CTOT-11 Study Investigators.

更新日期：2019-07-09 00:00:00

abstract：:This study compares the recommendations of the most recent American College of Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology (ESC)/European Society of Hypertension (ESH) blood pressure guidelines. Both guidelines represent updates of previous guidelines and reinforce previous con...

journal_title：Journal of the American College of Cardiology

authors： Bakris G,Ali W,Parati G

更新日期：2019-06-18 00:00:00

abstract：BACKGROUND:High systolic blood pressure (SBP) increases cardiac afterload, whereas low diastolic blood pressure (DBP) may lead to impaired coronary perfusion. Thus, wide pulse pressure (high systolic, low diastolic [HSLD]) may contribute to myocardial ischemia and also be a predictor of adverse cardiovascular events. ...

journal_title：Journal of the American College of Cardiology

authors： Warren J,Nanayakkara S,Andrianopoulos N,Brennan A,Dinh D,Yudi M,Clark D,Ajani AE,Reid CM,Selkrig L,Shaw J,Hiew C,Freeman M,Kaye D,Kingwell BA,Dart AM,Duffy SJ,Melbourne Interventional Group Investigators.

更新日期：2019-06-11 00:00:00

abstract：:The 2013 (with updates in 2016 and 2017) American College of Cardiology/American Heart Association and 2016 European Society of Cardiology guidelines provide practical evidence-based clinical guidelines for the diagnosis and treatment of both acute and chronic heart failure (HF). Both guidelines address noninvasive an...

journal_title：Journal of the American College of Cardiology

authors： van der Meer P,Gaggin HK,Dec GW

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:There is increasing evidence that current thresholds for diagnosing pulmonary hypertension (PHT) underestimate the prognostic impact of PHT. OBJECTIVES:The aim of this study was to determine the prognostic impact of increasing pulmonary pressures within the National Echocardiography Database of Australia co...

journal_title：Journal of the American College of Cardiology

authors： Strange G,Stewart S,Celermajer DS,Prior D,Scalia GM,Marwick TH,Gabbay E,Ilton M,Joseph M,Codde J,Playford D,NEDA Contributing Sites.

更新日期：2019-06-04 00:00:00

abstract：BACKGROUND:Guidelines recommend that patients with heart failure with reduced ejection fraction (HFrEF) have medical therapy titrated to target doses derived from clinical trials, as tolerated. The degree to which titration occurs in contemporary U.S. practice is unknown. OBJECTIVES:This study sought to characterize l...

journal_title：Journal of the American College of Cardiology

authors： Greene SJ,Fonarow GC,DeVore AD,Sharma PP,Vaduganathan M,Albert NM,Duffy CI,Hill CL,McCague K,Patterson JH,Spertus JA,Thomas L,Williams FB,Hernandez AF,Butler J

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Interstitial fibrosis is an important component of diastolic, and systolic, dysfunction in heart failure (HF) and depends on activation and differentiation of fibroblasts into myofibroblasts (MyoFb). Recent clinical evidence suggests that in late-stage HF, fibrosis is not reversible. OBJECTIVES:The study ai...

journal_title：Journal of the American College of Cardiology

authors： Nagaraju CK,Robinson EL,Abdesselem M,Trenson S,Dries E,Gilbert G,Janssens S,Van Cleemput J,Rega F,Meyns B,Roderick HL,Driesen RB,Sipido KR

更新日期：2019-05-14 00:00:00

abstract：:Exercise intolerance is the cardinal symptom of heart failure (HF) and is of crucial relevance, because it is associated with a poor quality of life and increased mortality. While impaired cardiac reserve is considered to be central in HF, reduced exercise and functional capacity are the result of key patient characte...

journal_title：Journal of the American College of Cardiology

authors： Del Buono MG,Arena R,Borlaug BA,Carbone S,Canada JM,Kirkman DL,Garten R,Rodriguez-Miguelez P,Guazzi M,Lavie CJ,Abbate A

更新日期：2019-05-07 00:00:00

abstract：BACKGROUND:It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting. OBJECTIVES:The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate th...

journal_title：Journal of the American College of Cardiology

authors： Stamatakis E,Gale J,Bauman A,Ekelund U,Hamer M,Ding D

更新日期：2019-04-30 00:00:00

abstract：:Defining left atrial (LA) function has recently emerged as a powerful parameter, particularly in evaluation of left ventricular (LV) diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction. Echocardiographic assessment of LVDD by echocardiography remains a challenging task; recent recommendatio...

journal_title：Journal of the American College of Cardiology

authors： Thomas L,Marwick TH,Popescu BA,Donal E,Badano LP

更新日期：2019-04-23 00:00:00

abstract：BACKGROUND:A combination of circulating biomarkers associated with excessive myocardial collagen type-I cross-linking or CCL+ (i.e., decreased carboxy-terminal telopeptide of collagen type-I to matrix metalloproteinase-1 ratio) and with excessive myocardial collagen type-I deposition or CD+ (i.e., increased carboxy-ter...

journal_title：Journal of the American College of Cardiology

authors： Ravassa S,Ballesteros G,López B,Ramos P,Bragard J,González A,Moreno MU,Querejeta R,Vives E,García-Bolao I,Díez J

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Transcatheter mitral valve replacement (TMVR) is a rapidly evolving therapy. Follow-up of TMVR patients remains limited in duration and number treated. OBJECTIVES:The purpose of this study was to examine outcomes with expanded follow-up for the first 100 patients who underwent TMVR with the prosthesis. MET...

journal_title：Journal of the American College of Cardiology

authors： Sorajja P,Moat N,Badhwar V,Walters D,Paone G,Bethea B,Bae R,Dahle G,Mumtaz M,Grayburn P,Kapadia S,Babaliaros V,Guerrero M,Satler L,Thourani V,Bedogni F,Rizik D,Denti P,Dumonteil N,Modine T,Sinhal A,Chuang ML,P

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:It is unclear whether the overall effectiveness and safety of direct oral anticoagulants (DOACs) are consistent in patients with nonvalvular atrial fibrillation (AF) and extremely low body weight (<50 kg). OBJECTIVES:This study compared DOACs with warfarin in AF patients with low body weight. METHODS:Using...

journal_title：Journal of the American College of Cardiology

authors： Lee SR,Choi EK,Park CS,Han KD,Jung JH,Oh S,Lip GYH

更新日期：2019-03-05 00:00:00

abstract：:Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl ester between high-density lipoprotein (HDL) and apolipoprotein B100-containing lipoproteins. Evidence from genetic studies that variants in the CETP gene were associated with higher blood HDL cholesterol, lower low-density...

journal_title：Journal of the American College of Cardiology

authors： Armitage J,Holmes MV,Preiss D

更新日期：2019-02-05 00:00:00

abstract：BACKGROUND:Circulating high-density lipoprotein particle (HDL-P) subfractions impact atherogenesis, inflammation, and endothelial function, all of which are implicated in the pathobiology of heart failure (HF). OBJECTIVES:The authors sought to identify key differences in plasma HDL-P subfractions between patients with...

journal_title：Journal of the American College of Cardiology

authors： Hunter WG,McGarrah RW 3rd,Kelly JP,Khouri MG,Craig DM,Haynes C,Felker GM,Hernandez AF,Velazquez EJ,Kraus WE,Shah SH

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Congenital heart defects are more frequent in offspring of mothers with overweight or obesity. However, associations between maternal overweight and obesity, and risks of complex and specific heart defects are not clear. OBJECTIVES:This study sought to analyze associations between maternal overweight and ob...

journal_title：Journal of the American College of Cardiology

authors： Persson M,Razaz N,Edstedt Bonamy AK,Villamor E,Cnattingius S

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Diabetes confers an increased risk for atherosclerotic cardiovascular disease, but less is known about the independent risk diabetes confers on major cardiovascular and limb events in patients with symptomatic peripheral artery disease (PAD) on contemporary management. OBJECTIVES:The authors sought to asses...

journal_title：Journal of the American College of Cardiology

authors： Low Wang CC,Blomster JI,Heizer G,Berger JS,Baumgartner I,Fowkes FGR,Held P,Katona BG,Norgren L,Jones WS,Lopes RD,Olin JW,Rockhold FW,Mahaffey KW,Patel MR,Hiatt WR,EUCLID Trial Executive Committee and Investigators.

更新日期：2018-12-25 00:00:00

abstract：BACKGROUND:His bundle pacing is a new method for delivering cardiac resynchronization therapy (CRT). OBJECTIVES:The authors performed a head-to-head, high-precision, acute crossover comparison between His bundle pacing and conventional biventricular CRT, measuring effects on ventricular activation and acute hemodynami...

journal_title：Journal of the American College of Cardiology

authors： Arnold AD,Shun-Shin MJ,Keene D,Howard JP,Sohaib SMA,Wright IJ,Cole GD,Qureshi NA,Lefroy DC,Koa-Wing M,Linton NWF,Lim PB,Peters NS,Davies DW,Muthumala A,Tanner M,Ellenbogen KA,Kanagaratnam P,Francis DP,Whinnett ZI

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:The pathophysiology of cardiomyopathy associated with premature ventricular contractions (PVCs) remains unclear. OBJECTIVES:This study prospectively explored cardiomyopathy development in a swine model of paced ectopic beats. METHODS:A total of 35 swine underwent pacemaker implantation. A group exposed to ...

journal_title：Journal of the American College of Cardiology

authors： Walters TE,Rahmutula D,Szilagyi J,Alhede C,Sievers R,Fang Q,Olgin J,Gerstenfeld EP

更新日期：2018-12-11 00:00:00

abstract：:Reduction in excess calories and improvement in dietary composition may prevent many primary and secondary cardiovascular events. Current guidelines recommend diets high in fruits, vegetables, whole grains, nuts, and legumes; moderate in low-fat dairy and seafood; and low in processed meats, sugar-sweetened beverages,...

journal_title：Journal of the American College of Cardiology

authors： Yu E,Malik VS,Hu FB

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:The BAG3 (BLC2-associated athanogene 3) gene codes for an antiapoptotic protein located on the sarcomere Z-disc. Mutations in BAG3 are associated with dilated cardiomyopathy (DCM), but only a small number of cases have been reported to date, and the natural history of BAG3 cardiomyopathy is poorly understood...

journal_title：Journal of the American College of Cardiology

authors： Domínguez F,Cuenca S,Bilińska Z,Toro R,Villard E,Barriales-Villa R,Ochoa JP,Asselbergs F,Sammani A,Franaszczyk M,Akhtar M,Coronado-Albi MJ,Rangel-Sousa D,Rodriguez-Palomares JF,Jiménez-Jáimez J,Garcia-Pinilla JM,Ripoll-Ve

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Neurological events after aortic valve interventions are associated with increased mortality and morbidity. Transcatheter aortic valve replacement (TAVR) is increasingly offered for lower-risk patients with severe aortic stenosis, previously considered candidates for surgical aortic valve replacement (SAVR)....

journal_title：Journal of the American College of Cardiology

authors： Durko AP,Reardon MJ,Kleiman NS,Popma JJ,Van Mieghem NM,Gleason TG,Bajwa T,O'Hair D,Brown DL,Ryan WH,Chang Y,De Leon SD,Kappetein AP

更新日期：2018-10-30 00:00:00

abstract：:Fine particulate matter <2.5 μm (PM2.5) air pollution is the most important environmental risk factor contributing to global cardiovascular (CV) mortality and disability. Short-term elevations in PM2.5 increase the relative risk of acute CV events by 1% to 3% within a few days. Longer-term exposures over several years...

journal_title：Journal of the American College of Cardiology

authors： Rajagopalan S,Al-Kindi SG,Brook RD

更新日期：2018-10-23 00:00:00

abstract：BACKGROUND:Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability. OBJECTIVES:This study investigated the prognostic value of WSS measured in the proximal seg...

journal_title：Journal of the American College of Cardiology

authors： Kumar A,Thompson EW,Lefieux A,Molony DS,Davis EL,Chand N,Fournier S,Lee HS,Suh J,Sato K,Ko YA,Molloy D,Chandran K,Hosseini H,Gupta S,Milkas A,Gogas B,Chang HJ,Min JK,Fearon WF,Veneziani A,Giddens DP,King SB 3r

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Diabetic medications can cause hypoglycemia, which may lead to myocardial damage. OBJECTIVES:This study sought to determine whether hypoglycemia is associated with higher levels of high-sensitivity cardiac troponin T (hsTnT). METHODS:The BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabete...

journal_title：Journal of the American College of Cardiology

authors： Rezende PC,Everett BM,Brooks MM,Vlachos H,Orchard TJ,Frye RL,Bhatt DL,Hlatky MA

更新日期：2018-10-09 00:00:00

abstract：BACKGROUND:Long-term benefits of off-pump versus on-pump coronary artery bypass grafting (CABG) are controversial. OBJECTIVES:The authors sought to compare long-term survival and morbidity after on-pump versus off-pump CABG. METHODS:Mandatory clinical and administrative registries from New Jersey Department of Health...

journal_title：Journal of the American College of Cardiology

authors： Chikwe J,Lee T,Itagaki S,Adams DH,Egorova NN

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Previous studies raised safety concerns on the association between fluoroquinolone treatment and serious collagen disorders, aortic aneurysm and dissection (AA/AD). OBJECTIVES:This study sought to evaluate this association via a case-crossover analysis in a large national administrative database. METHODS:A...

journal_title：Journal of the American College of Cardiology

authors： Lee CC,Lee MG,Hsieh R,Porta L,Lee WC,Lee SH,Chang SS

更新日期：2018-09-18 00:00:00